Endocrine Abstracts

In 1807, the Hunterian museum, the first public museum in Scotland, opened at the University of Glasgow. Its contents were bequeathed by William Hunter, a graduate of the university, and included, as well as anatomy specimens, books, coins, paintings, natural history specimens, ‘curiosities from the South Seas’, minerals, fossils and so forth. A letter of 1809 stated ‘Hunter’s museum has been here for some time and drawn a considerable number of students to...

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Background: Recent research on experiences of adults with a rare endocrine condition/disease (RED) indicate a preference for greater access to allied health professionals including physiotherapists.Objective: To explore experiences of musculoskeletal (MSK) symptoms (typically managed by physiotherapy) of adults living with a RED and investigate their reported usage and satisfaction of MSK physiotherapy services.Method: Ethically ap...

Purpose: To evaluate the impact of thyroid eye disease (TED) on occupational disability and access to psychological input. Previous European studies have demonstrated a negative effect of TED on occupation but there are no similar UK studies.Methods: 102 outpatients under the age of 75 were identified for participation from a joint thyroid eye clinic at a tertiary centre. 42 completed a standardised fixed-choice questionnaire about occupational disabilit...

One of the most significant health measures implemented during the COVID-19 pandemic has been extended periods of lockdown. Vitamin D is essential for many biological functions including pregnancy and bone health and modulate the immune system. Many studies also suggested a beneficial effect of replenished stores of vitamin D (25(OH)D >50 nmol/l) against severe and long term COVID-19 and self-supplementation is recommended by the government. Here we report on the vitamin D...

Background: Germline mutations in SDHB, SDHC, and SDHD cause hereditary phaeochromocytoma and paraganglioma (PGL) syndromes. The genotype-phenotype correlation of these mutations and relationship to penetrance is poor. Our objective was to assess characteristics of patients with SDH mutations seen in our dedicated multidisciplinary clinic.Methods: A retrospective observational study of patients attending from May 2005 to May 2010, approved as an institut...

Adult survivors of haematological malignancies are subject to a number of putative insults to the skeleton. Adverse impacts on bone mass include sex-hormone deficiency, radiotherapy, chemotherapy, inadequate nutrition and a generalised catabolic state. We assessed BMD using DXA at the lumbar spine (LS) and femoral neck (FN) in 34 women with POF, defined by secondary amenorrhoea, elevated gonadotropins, and low oestradiol levels. Mean age at diagnosis was 29.7 (range 14–45...

The optimal oestrogen dose required to maintain bone mass in young women who develop POF is contentious. We reviewed longitudinal BMD data in 21 women with POF resulting from multi-modality cancer therapy for haematological malignancies. The 21 women were of mean age 30.6 (range 17–45) years at onset of amenorrhoea and weight 64.1+/−11.2 kg. Primary diagnoses were acute myeloid leukaemia (n=12), chronic myeloid leukaemia (n=5), acute lymphocytic leukae...

Clinical practice suggests that low dose steroid treatment delivered locally to the site of action may rarely lead to disturbances of the hypothalamic-pituitary-adrenal axis. We present three clinical examples:Case 1: A 72 yr old man with a history of severe sinusitis was referred because of three episodes of profound anorexia, vomiting and proximal muscle weakness which coincided with discontinuing his Betnesol (betamethasone sodium phosphate 0.1%) nose...

Introduction: The androgen receptor (AR) mediates the peripheral effects of testosterone. The main mechanism of action for the AR is direct regulation of gene transcription. Available evidence suggests that the number of CAG repeats in exon-1 of the AR gene is negatively correlated with transcriptional activity of the AR and that CAG repeat number links to mortality rate in T2DM men. The aim of this analysis was to determine the association between CAG repeat number and all ca...